Listed Biotechnology Companies B

This Page Last Updated On 25/6/2024

BDX - BCAL Diagnostics Ltd

Company is developing a novel blood screening test to improve early diagnosis and monitoring of breast cancer. Underlying technology developed in the US and brought back to Australia in 2017 and company was listed in mid 2021. Basic technology based on breast cancer associated lipids hence the name BCAL Diagnostics. There was a 51% decrease to $13 million in 2022 with recent jump following announcement of product development agreement in the US. There was a 65% increase in 2023 to $25 million with positive results coming from study in US indicating improved route to commercialisation of key test and achieving milestone in development of diagnostic for breast cancer. There has been an 11% increase in 2024 to $35 million with new CEO appointed, commercial director engaged and funds being raised for research and development and next product launch. (14/6/24)

BGT - Bio-Gene Technology Ltd.

Agtech development company following in the footsteps of Bioprospect with a novel platform technology based on naturally occurring chemicals for insecticide applications. Listed in late November 2017 and shares declined 3% by the end of the year with company value at $25 million. There was a 49% decrease in 2018 to $13 million with withdrawal of Virbac from testing program and laboratory tests showing efficacy against range of crop pests but relative non-toxicity for bees. There was a 100% increase in 2019 with company value at $27 million apparently based on speculation over positive trial results. There was a 30% decrease in 2020 with company value at $21 million and new funds raised. There was a 46% increase in 2021 with company value at $35 million with signing of agreements for garden pest control and mosquito control. There was a 51% decrease in 2022 to $18 million with signing of new development agreement, exit of BASF from study and application for plant breeders rights for trees with high levels of tasmanone. There was a 40% decrease in 2023 to $12 million with extension of development agreement and commercial outlook improving. There has been a 23% decrease in 2024 to $9 million. (23/6/24)

BIO - Biome Australia Ltd.

Company was founded in 2018 and is involved in development and marketing of complimentary medicines including nutraceuticals and live biotherapeutics. It listed in November 2021 at an indicative value of $40 million. There was a 40% decrease in 2022 to $14 million with sales increasing. There was a 186% increase in 2023 to $40 million with sales outlook promising, positive clinical trial results and release of new products. There has been a further 130% increase in 2024 to $98 million with annual projections revised upwards and launch of retail products in England and Ireland and approval in Canada. (20/6/24)

BIT - Biotron Ltd.

When Biotron listed a decade ago, it was hard to determine the justification for listing. Following listing, prices dropped 50%, bottoming at 17¢ in July 2004 then bouncing to over 30¢ before gradually declining to around 9¢ with speculative rises due to research findings on potential anti-influenza and anti-HIV products. The company had a market cap of $20 million at the end of 2011 which was high, and prices were expected to fall again as the company had not yet indicated any substance. In early 2007, prices which were level in 2006 spiked up 60% as a result of speculation over early laboratory results with one of Biotron's compounds but by year's end were down 22%. Shares oscillated wildly in 2008 and a jump was unexplained (down 33%). There was some uncertainty in 2009 (down 20%) with little signs of routes to commercialisation and prices rose 26% in 2010 due to heightened expectations for clinical trial results. There were price oscillations in 2011 (eventually up 4%) associated with a new round of fund raising and positive results in clinical trials. Raising of new funds and optimism about the future increased share prices in 2012 initially but there was then a decline followed by a temporary 50% jump with announcement of positive early trial results (eventually up 8% at $31 million). There was a 44% decline in 2013 to $17 million despite the announcement of encouraging trial results. There was a 38% increase to $29 million in 2014 with trials in Thailand indicating successful treatment of HCV infection with BIT225 and resulting in further fund raising. There have been price oscillations in 2015 and a 40% drop with announcement of higher than expected drop outs in clinical trials, eventually down 51% at $16 million with new fund raising successful. There had been a 4% decline in 2016 to $15 million but the announcement that compounds were being tested against Zika virus and publication of recent research resulted in a 30% lift and a further lift with announcement of positive results in phase 2 trial of BIT225 in treating Hepatitis C infection and activity of compounds against Zika virus (eventually down 24% at $12 million). There was a 26% decrease in 2017 to $11 million associated with a 1:4 rights issue to raise more funds. A temporary jump in price resulted from promising preclinical testing of products against Hepatitis B Virus. There was a 297% increase in 2018 to $68 million following announcement of positive clinical trial results and new fund raising. There was a 55% decline in 2019 with company value at $37 million with little sign of commercial progress. There was a 50% recovery in 2020 to $55 million with considerable speculation over announcement that BIT would test its compounds against Coronavirus (Covid-19) having found specific targets in Coronaviruses. Further screening has found around 15 possible drug candidates. There was a 24% increase to $68 million in 2021 with a recent 100% jump with announcement that a compound was effective against Covid 19 and advances in HIV and Covid clinical trials. There was a 72% decrease in 2022 to $24 million with tests in animals showing effectiveness against Covid 19, new HIV trial starting and substantial funds raised. There was a 259% increase in 2023 at $88 million with key trial for treatment of Covid completed and speculation over results of trials for treatment of HIV and Covid. There has been a 56% decrease in 2024 to $39 million despite positive preliminary clinical trial results. (25/6/24)

(BNO - Bionomics Ltd.)

The share price of the company dropped to a low of 20¢ at the end of July 2004 then increased 50% up to the end of November 2004 due to a strong push to have alliances in the US and Europe, but retreated to the 20¢ level since then, despite the merger with Iliad Chemicals. Following the merger, associated capital raising and recent announcements of licensing arrangements, there has been some price oscillation. We expected share prices to remain at around these levels or increase if further alliances with the US and Europe could be built. In the longer term, the company will need to demonstrate significantly increased revenues (gradually occurring) and eventually profitability. There were no major changes in prices in 2006 (up 4%) but with the announcement of a new CRC for Cancer Therapy which would be closely associated with Bionomics, there was a jump in early 2007 followed up by new candidate drugs in the pipeline (up 79% in 2007). There was a fall and recovery in 2008 (down 46%). The company had a market cap of $99 million at the end of 2010 which was reasonable (up 67% in 2009 with announcement of $15 million placement but down 17% in 2010). There was an 105% increase in 2011 to $219 million with announcement of positive clinical trials, positive promotion in the market and sale of majority of Start up Australia holding as well as new funds raised. However general share market downturn has affected prices (eventually up 90% at $203 million). There was a 57% decline to $88 million in 2012 despite announcement of collaboration with Ironwood Pharmaceuticals and significantly improved financials but positive end of year financials provided a temporary recovery as well as acquisition of US cancer stem cell company Eclipse Therapeutics and announcement of new drug candidate (eventually down 39% at $131 million). There was a 15% increase in early 2013 to $151 million with advancement of clinical trials reported but a fall once a new fund raising round announced. There was a further spurt with signing of agreement with Merck (up 110% in 2013 to $311 million). There has been a fall in 2014 associated with release of clinical trial data and a significant recovery with announcement of new agreement with Merck with a subsequent recovery associated with favourable clinical trial data and acquisition of Prestwick Chemical in France to improve vertical integration and link with important client base (eventually down 43% to $180 million). There was a 14% decrease in 2015 to $178 million with FDA approving IND for new anticancer candidate, positive results from clinical trials and extension of agreement with Merck as well as a significant new investment in the company by Merck and further fund raising to support a trial on treatment of post traumatic stress disorder which occasioned a 25% fall in share price. There was a further 26% decline in 2016 to $132 million with substantial new funds being raised but at a recent extraordinary general meeting, shareholders did not support issuing shares to new investors. So much so that a 5% holder, CVC called for a General Meeting to remove the chairman and one other director with the claim that flawed board decisions had significantly eroded the company's value. This resulted in some turnover of the board. Positive trial results resulted in a 40% jump in prices which then dissipated (eventually down 11% at $159 million). There was a 17% recovery in 2017 to $186 million and there was a 36% increase in 2018 to $253 million with the company gaining high profile overseas. However, announcement in early October that a trial to treat Post Traumatic Stress Disorder did not meet the primary endpoint resulted in a 60% share fall (eventually down 73% at $57 million following recapitalisation). An Executive Chairman has taken over the management of the company with the retirement of the Managing Director and BVF Partners is recapitalising the company moving to 20% shareholding. There was a 29% recovery in 2019 to $74 million as further analysis of negative trial results provided some optimism but lack of progress on this and delay in progress with Merck was causing concern and led to a fall which was exacerbated by a further negative clinical trial result but positive preclinical results resulted in a temporary price surge (eventually down 26% to $42 million). Company has completed sale of French subsidiaries to Domain Therapeutics. There was an 86% increase in 2020 to $102 million with substantial new funds raised through recapitalisation and proposed acquisitions. There was a 24% decrease in 2021 to $144 million with funds raised and speculation pushing up prices but with financials remaining limiting. Company has completed US IPO. There was a 67% decrease in 2022 to $53 million with a 30% drop following announcement of negative clinical results. New President/CEO appointed to start in January 2023. There has been a 72% decrease in 2023 to $14 million with change of management to prepare for shift to US operations and announcement to delist from ASX by end of August and retain listing on NASDAQ. (30/8/23)

BOT - Botanix Pharmaceuticals Ltd.

Name changed from Bone Medical to Botanix Pharmaceuticals at end of June 2016 with acquisition of US company Botanix Pharmaceuticals which had a drug delivery technology for treating acne and psoriasis. There was a consolidation of shares with the acquisition and a name change approved by shareholders. Shares up 16% in 2016 after relisting with value of $11 million following good promotion in the market. There was a 50% increase in 2017 to $23 million with ethics approval for trial involving cannabidiol, promising preclinical results and substantial new funds raised. There was a 6% increase in 2018 to $53 million with increasing market interest in cannabis products and positive results in clinical trials with planning to fast track next clinical trials as well as raising of substantial new funds. There was a further 257% increase in 2019 to $241 million due to positive preclinical and clinical trial results with lead compounds and substantial fund raising. However, equivocal clinical results led to a more than 50% drop in share price (eventually up 17% at $80 million in 2019). There was a 52% increase in 2020 to $122 million with a 60% drop resulting from a clinical trial not meeting endpoints and a recent jump associated with FDA designation given to an antibacterial product. There was a 55% decrease in 2021 to $54 million. There was a 5% decrease in 2022 to $63 million with funds raised and positive clinical trial announced. There was a 253% recovery in 2023 to $294 million with an improving outlook and FDA positive review and speculation supporting prices. There has been a 74% increase in 2024 to $519 million. (15/6/24)

BP8 - BPH Global Ltd.

Singapore-based company originally called Stemcell United using proprietary stem cell technology to culture and grow plant extracts for use in traditional Chinese medicine had changed name from On Q Group in September 2015. Following the previous name change, shares fell 87% and in 2016, 83% to a company value of $6 million and were down 7% in 2017 to $5 million. The announcement in March 2017 that company was leveraging its position in complementary medicine to move into medicinal cannabis resulted in shares jumping a highly speculative 1,221% to a company value of $77 million. This speculation persisted with questions being asked about the viability of the company's fundamental business and a further 75% price jump was also unexplained (eventually up 186% at $17 million). There was a decrease and recovery to $12 million in 2018 (down 40%) with an entitlements issue to raise further funds dampening prices (61% shortfall to be underwritten). Speculation over discussions in China on returning to the cannabis story resulted in a short term suspension of share trading and announcement that related Chinese company had gained a hemp licence provided at least a short term recovery. Following this, shares were down 43% at $12 million but there was recently a speculative 50% jump in share prices which remains unexplained (eventually down 53% at $10 million). There was a 26% decrease in 2019 with company value at $9 million following new fund raising and completion of acquisition in China in hemp market. There was a 29% decrease in 2020 to $6 million with a move to increase operations in the cannabis market but following new collaboration in Singapore the price has recovered. There was further stimulation with announcement of new sea farming venture in Singapore and China (eventually up 36% at $15 million). There was a 26% decrease in 2021 to $15 million with funds raised. There was a suspension of share trading in September 2021 re an announcement of joint venture. This continued although the joint venture was terminated with revenues up in aquaculture products and losses down and a prospectus was in preparation for return to trading. There was a change in the board preparatory to an extraordinary meeting with likely changes in shareholdings and shift away from sea-grape production and move to seaweed cultivation. The company was making slow progress to reinstatement and a new funding was in place. Company was reinstated to official quotation on 30 March 2023 and prices fell 93% to company value of $1.7 million with shareholders changing the name of the company to BPH Global (ASX:BP8) in June and change of Managing Director. Company has shareholder agreement to a 5:1 share consolidation and is preparing for pilot study of human milk in China. Shares down 40% since consolidation with company value at $1.2 million. (23/6/24)

BTC - BTC health Ltd.

Originally called Biotech Capital and then name changed to BTC health in November 2017. After relatively stable prices in the mid 40¢ range during 2004, prices fell 15% in 2005 in line with declines in the biotech sector in 2005 but recovered to their former trading band until late 2006. The company appeared to be losing momentum in late 2006 and prices declined significantly, and this was partly countered by share buyback (down 7% in 2006). The decline continued in 2007 (down 20%), in 2008 (down 63%), in 2009 up 161% and down 58% in 2010. The company had a market cap of $3 million which was less than its reported net asset backing of $4.1 million even after write offs. The company was considering alternative options for moving forward including removal of pooled development fund status and investment outside the biotech industry. This culminated in board change suggesting move out of life science sector. Share buyback was supporting price but with the change this was no longer effective as there were questions about the value of the company's portfolio and more write offs were likely. Prices oscillating and eventually down 43% in 2011 with dividends being paid and shareholdings being offloaded for around half of book value prior to restructure of company. There was an unexplained and temporary 41% lift in early 2012: eventually down 51% with only one unsold investment remaining in portfolio and departure of Chairman. There was a further temporary decline in 2013 with questions asked about the net tangible asset valuation of the company and share trading. Even in 2014 and no explanation for a 30% temporary jump in prices. In July 2014, there was a change of Board members with new funds injected and a 268% increase in share price to company value of $8 million with speculation as to future activities of the company with a major shareholder increasing share. There was a 9% increase in 2015 to $10 million with the injection of funds by Lang Walker and change of Board but the company has indicated it only had net tangible backing of less than $2 million suggesting the extent of speculation. Company has moved from WA to Victoria. In 2016 shares up 15% at $12 million with acquisition of advisory company Biointelect, major shareholder selling out and investment in bio101 Group as well as paying Chairman consulting fees instead of lower director fees. Shares up 100% to $30 million in 2017 with new funds raised and change of company name to BTC Health in November 2017. There was a 39% decline in 2018 to $18 million and company divested its consultancy subsidiary with downward valuation of its tangible assets to less than $3 million. There was a 21% decrease in 2019 to $27 million with subsidiary making progress on licensed product and acquiring infusion business from Admedus for which BTC has raised capital and the distributor Sigma becomes a significant shareholder. There was a further 45% increase in early 2020 to $39 million without clear explanation but with the Coronavirus crisis, shares fell to company value of $21 million (down 21%). There was a 13% decrease in 2021 with company value at $21 million and raising funds for move into mannitol drug distribution. There was a 51% decrease in 2022 to $10 million. There was a 41% increase in 2023 to $17 million with funds raised, entry into new businesses and TGA approval for infusion pump. There has been 23% decrease in 2024 to $13 million. with new distribution agreement signed. (25/6/24)

BXN - Bioxyne Ltd.

Formed from merger of Probiomics and Hunter Immunology in April 2012 with a market value at the time of around $30 million. Since listing, there was a 15% increase to $34 million apparently on basis of speculation and a sharp reversal in June 2012 with announcement of results of clinical trial (down 85% to $5 million). Shareholder meeting unseated three directors and an agreement was in negotiation for sale of probiotics business and sale of equity to Vaxine for $4.3 million to continue trials. A further meeting of shareholders in December resulted in the departure of two more directors, a refutation of the strategy of the company and further price falls (down 93% to $2 million). An eventual result was the exit of the CEO and replacement with an interim CEO who is a major shareholder. There was a 7% increase in 2013 initially without explanation but due to speculation over proposal for acquisition of Vitality, a marketing company formed by ex-executives of Chemgenex. This acquisition did not proceed and value of company fell 29% in 2013 to $2 million with sale of COPD technology to Mariposa Health. There was an unexplained recovery in 2014 with financials improving and temporary profitability (up 40% to $3 million). Up 57% in 2015 at $4 million with sales of probiotics higher than expected and deal with Mariposa likely to provide unprojected income. Down 18% in 2016 at $4 million and up 121% in 2017 at $21 million with acquisition of product development company, new CEO and new funds raised. There was a 300% jump in December 2017 with the launch of new dairy formula products in South East Asia (eventually up 411% at $59 million). There was a 64% decrease in 2018 to $21 million and a further 58% decrease in 2019 to $9 million. There was a 14% decrease in 2020 with company value at $8 million. There was an unexplained 142% increase in 2021 with company value at $19 million. There was a 17% decrease in 2022 to $16 million with sale of 49% of Direct Selling Business to Singapore partner Paramount and proposed acquisition of Breathe Life Sciences for $37 million in BXN shares. There was a 54% decrease in 2023 to $21 million with business of Breathe Life Sciences expanding and in JV for new platform . There has been a 55% decrease in 2024 to $10 million with funds raised and move into psilocybin therapies. (25/6/24)